Predictors of Medication Adherence among Patients with Bipolar I Disorder
DOI:
https://doi.org/10.52053/jpap.v4i2.180Keywords:
Awareness Campaign, Bipolar I Disorder, Internalized Stigmatization, Medication Adherence, Perceived Social SupportAbstract
The present study aimed to determine predictors of medication adherence among patients diagnosed with Bipolar I Disorder (BP-I). Another aim was to estimate differences with different marital status in perceived social support, internalized stigmatization and medication adherence. Correlational research design was used and a sample of 103 participants was gathered using purposive sampling method. Data was collected by administering Multidimensional Scale of Perceived Social Support (MSPSS), Internalized Stigma of Mental Illness (ISMI), and General Medication Adherence Scale (GMAS). Results illustrated perceived social support (R2 = .46, F (3, 99) = 28.52, p<0.001) and internalized stigmatization R2 = .49, F (8, 94) = 11.40, p<0.001) to be significant predictors of medication adherence. Furthermore, it was found that married individuals with bipolar I disorder received more support [F (1, 101) = 4.08, p = .04] and were more adherent to medication [F (1, 101) = 6.35, p = .01] as compared to single individuals with bipolar I disorder. However, no significant difference was found between married and single patients in their experience of internalized stigmatization. Present study highlights the need for awareness campaign where individuals are informed regarding the importance of their support and also the need for educational workshops for skill building in patients with Bipolar I disorder.
References
Adnan, M., Khan, T., Razzaq, B., Ghaffar, R., Batool, S., Shehzadi, I., Qayum, M., Mustafa, A. B., Hussain, F., & Makhdoom, B. J. (2021). Quality of life and Social Support Among Diagnose Bipolar Patients. Pakistan Journal of Medical and Health Sciences, 15(5), 932–935. https://doi.org/10.53350/pjmhs21155932 DOI: https://doi.org/10.53350/pjmhs21155932
Ahmad, S. S., & Koncsol, S. W. (2022). Cultural Factors Influencing Mental Health Stigma: Perceptions of Mental Illness (POMI) in Pakistani Emerging Adults. Religions, 13(5), 401.https://doi.org/10.3390/rel13050401 DOI: https://doi.org/10.3390/rel13050401
Ahmed, S.A., & Gemeay, E.M. (2017). Perceived social support and medication compliance among patients with psychiatric disorders. International Journal of Novel Research in Healthcare and Nursing, 4 (3), 157-169.
Akhtar, A., Rahman, A., Husain, M., Chaudhry, I. B., Duddu, V., & Husain, N. (2010). Multidimensional scale of perceived social support: Psychometric properties in a South Asian population. Journal of Obstetrics and Gynaecology Research, 36(4), 845–851. https://doi.org/10.1111/j.1447-0756.2010.01204. DOI: https://doi.org/10.1111/j.1447-0756.2010.01204.x
Altamura, C.A., Buoli, M., Cesana, B., Dell-Osso, B., Tacchini, G., Albert, U., Fagiolini, A., de Bartolomeis, A., Maina, G., & Sacchetti, E. (2018). Socio-demographic and clinical characterization of patients with bipolar disorder I vs II: nationwide Italian study. European Archives of Psychiatry and Clinical Neuroscience, 268, 169-177. https://doi.org/10.1007/s00406-017-0791-0 DOI: https://doi.org/10.1007/s00406-017-0791-0
American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.). https://doi.org/10.1176/appi.books.9780890425787 DOI: https://doi.org/10.1176/appi.books.9780890425787
Baloush-Kleinman, V., Levine, S. Z., Roe, D., Shnitt, D., Weizman, A., & Poyurovsky, M. (2011). Adherence to antipsychotic drug treatment in early-episode schizophrenia: A six- month naturalistic follow-up study. Schizophrenia Research, 130 (1-3), 176–181. doi:10.1016/j.schres.2011.04.030 DOI: https://doi.org/10.1016/j.schres.2011.04.030
Benedetti, F., Aggio, V., Pratesi, M. L., Greco, G., & Furlan, R. (2020). Neuroinflammation in Bipolar Depression. Frontiers in Psychiatry, 11, 71. https://doi.org/10.3389/fpsyt.2020.00071 DOI: https://doi.org/10.3389/fpsyt.2020.00071
Boyd, J. E., Adler, E. P., Otilingam. P. O., & Peters, T. (2013). Internalized stigma of mental illness (ISMI) scale: A multinational review. Comprehensive Psychiatry.http://dx.doi.org/10.1016/j.comppsych.2013.06.005 DOI: https://doi.org/10.1016/j.comppsych.2013.06.005
Carvalho, A. F., Firth, J., & Vieta, E. (2020). Bipolar Disorder. New England Journal of Medicine, 383(1), 58–66. doi:10.1056/nejmra1906193 DOI: https://doi.org/10.1056/NEJMra1906193
Chakrabarti S. (2016). Treatment-adherence in bipolar disorder: A patient-centered approach. World Journal of Psychiatry, 6(4), 399–409. https://doi.org/10.5498/wjp.v6.i4.399 DOI: https://doi.org/10.5498/wjp.v6.i4.399
Chang, C. C., Wu, T. H., Chen, C. Y., Wang, J. D., & Lin, C. Y. (2014). Psychometric Evaluation of the Internalized Stigma of Mental Illness Scale for Patients with Mental Illnesses: Measurement Invariance across Time. PLoS ONE, 9(6), e98767. https://doi.org/10.1371/journal.pone.0098767 DOI: https://doi.org/10.1371/journal.pone.0098767
Corrigan, P. W., Rafacz, J., & Rüsch, N. (2011). Examining a progressive model of self-stigma and its impact on people with serious mental illness. Psychiatry Research, 189(3), 339– 343. https://doi.org/10.1016/j.psychres.2011.05.024 DOI: https://doi.org/10.1016/j.psychres.2011.05.024
Cunningham, R., Crowe, M., Stanley, J., Haitana, T., Pitama, S., Porter, R., Baxter, J., Huria, T., Mulder, R., Clark, M. T. R., & Lacey, C. (2020). Gender and mental health service use in bipolar disorder: national cohort study. BJ Psychiatry Open, 6(6). https://doi.org/10.1192/bjo.2020.117 DOI: https://doi.org/10.1192/bjo.2020.117
Dahlem, N. W., Zimet, G. D., & Walker, R. R. (1991). The Multidimensional Scale of Perceived Social Support: A confirmation study. Journal of Clinical Psychology, 47(6), 756–761. https://doi.org/3.0.co;2-l">10.1002/1097-4679(199111)47:6<756::aid- jclp2270470605>3.0.co;2-l DOI: https://doi.org/10.1002/1097-4679(199111)47:6<756::AID-JCLP2270470605>3.0.CO;2-L
Dell’Osso, B., Cafaro, R., & Ketter, T. A. (2021). Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies. International Journal of Bipolar Disorder, 9 (3). https://doi.org/10.1186/s40345-020-00207-z DOI: https://doi.org/10.1186/s40345-020-00207-z
De Maria, M., Tagliabue, S., Ausili, D., Vellone, E., & Matarese, M. (2020). Perceived social support and health-related quality of life in older adults who have multiple chronic conditions and their caregivers: a dyadic analysis. Social Science & Medicine, 262, 113193. https://doi.org/10.1016/j.socscimed.2020.113193 DOI: https://doi.org/10.1016/j.socscimed.2020.113193
El-Azzab, S., & Ali, M. S. (2021). Social support, coping with stress and medication compliance among patients with bipolar disorder. Egyptian Journal of Nursing and Health Sciences, 2 (2), 227-248. DOI: https://doi.org/10.21608/ejnhs.2021.196028
Emerson, E., Fortune, N., Llewellyn, G., & Stancliffe, R. (2020). Loneliness, Social Support, Social Isolation and Wellbeing among Working Age Adults with and without Disability: Cross sectional study. Disability and Health Journal, 14(1), 100965. https://doi.org/10.1016/j.dhjo.2020.100965 DOI: https://doi.org/10.1016/j.dhjo.2020.100965
Engel, G. (1997). From biomedical to biopsychosocial: Being scientific in the human domain. Psychosomatics, 38, 521-528. http://dx.doi.org/10.1016/S0033-3182(97)71396-3 DOI: https://doi.org/10.1016/S0033-3182(97)71396-3
Faraji, E., Sardashti, S., Firouzeh, M.M., Aminabad, F. J., Alinaghi, S. A. S., & Hajiabdolbaghi, M. (2015). Perceived social support affects disease coping among people living with HIV: a study in Tehran, Iran. Asian Pacific Journal of Tropical Disease, 5, 412– 417. DOI: https://doi.org/10.1016/S2222-1808(14)60806-9
Feder, K. A., Heatherington, L., Mojtabai, R., & Eaton, W. W. (2019). Perceived Marital Support and Incident Mental Illness: Evidence from the National Comorbidity Survey. Journal of Marital and Family Therapy, 45(4), 668–683. https://doi.org/10.1111/jmft.12343 DOI: https://doi.org/10.1111/jmft.12343
Feldhaus, T., Falke, S., Gruchalla, L., Maisch, B., Uhlmann, C., Bock, E., Lencer, R. (2019). The impact of self-stigmatization on medication attitude in schizophrenia patients. Psychiatry Research, 261, 391-399. DOI: https://doi.org/10.1016/j.psychres.2018.01.012
Gast, A., & Mathes, T. (2019). Medication Adherence Influencing Factors—an (updated) Overview of Systematic Reviews. Systematic Reviews, 8(1).https://doi.org/10.1186/s13643-019-1014-8 DOI: https://doi.org/10.1186/s13643-019-1014-8
Grover, S., Nehra, R., & Thakur, A. (2017). Bipolar affective disorder and its impact on various aspects of marital relationship. Industrial Psychiatry Journal, 26(2), 114. https://doi.org/10.4103/ipj.ipj_15_16 DOI: https://doi.org/10.4103/ipj.ipj_15_16
Harandi, T. F., Taghinasab, M. M., & Nayeri, T. D. (2017). The correlation of social support with mental health: A meta-analysis. Electronic Physician, 9(9), 5212–5222. https://doi.org/10.19082/5212 DOI: https://doi.org/10.19082/5212
Hassan, S.S., & Zaki, S.M. (2018). Social Support and Its Relation with Medication Adherence among Patients with Psychiatric Illness. Journal of Nursing and Health Science, 7 (1), 64-71. DOI: 10.9790/1959-0701046471
Hsiao, C.-Y., Lu, H.-L., & Tsai, Y.-F. (2017). Effect of family sense of coherence on internalized stigma and health-related quality of life among individuals with schizophrenia. International Journal of Mental Health Nursing, 27(1), 138–146. doi:10.1111/inm.12302 DOI: https://doi.org/10.1111/inm.12302
Jawad, I., Watson, S., Haddad, P. M., Talbot, P. S., & McAllister-Williams, R. H. (2018). Medication nonadherence in bipolar disorder: a narrative review. Therapeutic Advances in Psychopharmacology, 349–363. https://doi.org/10.1177/2045125318804364 DOI: https://doi.org/10.1177/2045125318804364
Jimmy, B., & Jose, J. (2011). Patient Medication Adherence: Measures in Daily Practice. Oman Medical Journal, 26(3), 155–159. https://doi.org/10.5001/omj.2011.38 DOI: https://doi.org/10.5001/omj.2011.38
Korkmaz, G., & Küçük, L. (2016). Internalized Stigma and Perceived Family Support in Acute Psychiatric In-Patient Units. Archives of Psychiatric Nursing, 30(1), 55–61. doi:10.1016/j.apnu.2015.10.003 DOI: https://doi.org/10.1016/j.apnu.2015.10.003
Kvarnström, K., Westerholm, A., Airaksinen, M., & Liira, H. (2021). Factors Contributing to Medication Adherence in Patients with a Chronic Condition: A Scoping Review of Qualitative Research. Pharmaceutics, 13(7), 1100. https://doi.org/10.3390/pharmaceutics13071100 DOI: https://doi.org/10.3390/pharmaceutics13071100
McIntyre, R. S., Alda, M., Baldessarini, R. J., Bauer, M., Berk, M., Correll, C. U., Fagiolini, A., Fountoulakis, K., Frye, M. A., Grunze, H., Kessing, L. V., Miklowitz, D. J., Parker, G., Post, R. M., Swann, A. C., Suppes, T., Vieta, E., Young, A., & Maj, M. (2022). The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management. World Psychiatry, 21(3), 364–387. https://doi.org/10.1002/wps.20997 DOI: https://doi.org/10.1002/wps.20997
Naqvi, A., Hassali, M., Rizvi, M., Zehra, A., Iffat, W., Haseeb, A., & Jamshed, S. (2018). Development and validation of a novel General Medication Adherence Scale (GMAS) for chronic illness patients in Pakistan. Frontiers in Pharmacology, 9, 1124. doi.10.3389/fphar.2018.01124 DOI: https://doi.org/10.3389/fphar.2018.01124
Pakistan Bureau of Statistics (2017). Final Results of Census-2017 | Pakistan Bureau of Statistics. Pbs.gov.pk. https://www.pbs.gov.pk/content/final-results-census-2017-0
Shafiq, S. (2020). Perceptions of Pakistani community towards their mental health problems: a systematic review. Global Psychiatry, 0(0). https://doi.org/10.2478/gp-2020-0001 DOI: https://doi.org/10.2478/gp-2020-0001
Shahin, W., Kennedy, G. A., & Stupans, I. (2021). The association between social support and medication adherence in patients with hypertension: A systematic review. Pharmacy Practice, 19(2), 2300. https://doi.org/10.18549/pharmpract.2021.2.2300 DOI: https://doi.org/10.18549/PharmPract.2021.2.2300
Tesfaye, E., Worku, B., Girma, E., & Agenagnew, L. (2020). Internalized stigma among patients with mood disorders in Ethiopia: a cross-sectional facility-based study. International Journal of Mental Health Systems, 14, 32. https://doi.org/10.1186/s13033-020-00365-8 DOI: https://doi.org/10.1186/s13033-020-00365-8
Ustundag, M.F., & Kesebir, S. (2013). Internalized stigmatization in bipolar patients: relationship with clinical properties, quality of life and treatment compliance. Turkish Journal of Psychiatry. 24(4); 231–9. DOI: 10.5080/u7123 DOI: https://doi.org/10.5080/u7123
Vaingankar, J. A., Abdin, E., Chong, S. A., Shafie, S., Sambasivam, R., Zhang, Y. J., Chang, S., Chua, B. Y., Shahwan, S., Jeyagurunathan, A., Kwok, K. W., & Subramaniam, M. (2020). The association of mental disorders with perceived social support, and the role of marital status: results from a national cross-sectional survey. Archives of Public Health, 78(1). https://doi.org/10.1186/s13690-020-00476-1 DOI: https://doi.org/10.1186/s13690-020-00476-1
Wadood, Md. A., Karim, Md. R., Hussain, A. A. M., Rana, Md. M., & Hossain, Md. G. (2021). Bipolar disorder and self-perceived interpersonal relationships in the family: A household cross-sectional study among married adults in Rajshahi city, Bangladesh. Journal of Affective Disorders Reports, 5, 100169. https://doi.org/10.1016/j.jadr.2021.100169 DOI: https://doi.org/10.1016/j.jadr.2021.100169
Zimet, G. D., Dahlem, N. W., Zimet, S. G., & Farley, G. K. (1988). The Multidimensional Scale of Perceived Social Support. Journal of Personality Assessment, 52(1), 30-41. https://doi.org/10.1207/s15327752jpa5201_2 DOI: https://doi.org/10.1207/s15327752jpa5201_2
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